Abstract
The discovery and efficacy of a series of potent aminopyrrolidineamide-based inhibitors of sterol regulatory element binding protein site-1 protease is described.
MeSH terms
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Active Transport, Cell Nucleus / drug effects
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Animals
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Combinatorial Chemistry Techniques
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Gene Expression Regulation
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Humans
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Hypolipidemic Agents / chemistry
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Hypolipidemic Agents / pharmacology
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Inhibitory Concentration 50
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Male
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Mice
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Molecular Structure
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Proprotein Convertases / antagonists & inhibitors*
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Pyrroles / chemistry
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Pyrroles / pharmacology*
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Serine Endopeptidases
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Sterol Regulatory Element Binding Proteins / metabolism
Substances
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Hypolipidemic Agents
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Pyrroles
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Sterol Regulatory Element Binding Proteins
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Proprotein Convertases
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Serine Endopeptidases
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membrane-bound transcription factor peptidase, site 1